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Título Structural bioinformatics / edited by Jenny Gu, Philip E. Bourne

Publicación Hoboken, New Jersey : Wiley-Blackwell, cop. 2009
Ubicación Signatura Tipo de préstamo Estado Notas
 B. Ciencias. Física/Química-Depósito  SL 46-2    PRÉSTAMO LARGO  DISPONIBLE
Edición 2nd ed.
Descripción física XXVI, 1035 p. : il. col. y n. ; 27 cm
Bibliografía Bibliografía referencias e índice
Contiene: Section I. Data collection, analysis, and visualization -- 1. Defining bioinformatics and structural bioinformatics -- 2. Fundamentals of protein structure -- 3. Fundamentals of DNA and RNA structure -- 4. Computational aspects of high-throughput crystallographic macromolecular structure determination -- 5. Macromolecular structure determination by NMR spectroscopy -- 6. Electron microscopy in the context of structural systems biology -- 7. Study of protein three-dimensional structure and dynamics using peptide amide hidrogen/deuterium exchange mass spectrometry (DXMS) and chemical cross-linking with mass spectrometry to constrain molecular modeling -- 8. Search and sampling in structural bioinformatics -- 9. Molecular visualization -- Section II. Data representation and databases -- 10. The PDB format, mmCIF formats, and other data formats -- 11. The worldwide protein data bank -- 12. The nucleic acid database -- 13. Other structure-based databases -- Section III. Data integrity and comparative features -- 14. Structural quality assurance -- 15. The impact of local accuracy in protein and RNA structures: Validation as an active tool -- 16. Structure comparison and alignment -- 17. Protein structure evolution and the scop database -- 18. The cath domain structure database -- Section IV. Structural and functional assignment -- 19. Secondary structure assignment -- 20. Identifying structural domains in proteins -- 21. Inferring protein function from structure -- 22. Structural annotation of genomes -- 23. Evolution studied using protein structure -- Section V. Macromolecular interactions -- 24. Electrostatic interactions -- 25. Prediction of protein-nucleic acid interactions -- 26. Prediction of protein-protein interactions from evolutionary information -- 27. Docking methods, ligand design, and validating data sets in the structural genomics era -- Section VI. Structure prediction -- 28. Casp and other community-wide assessments to advance the field of structure prediction -- 29. Prediction of protein structure in 1D: Secondary structure, membrane regions, and solvent accessibility -- 30. Homology modeling -- 31. Fold recognition methods -- 32. De novo protein structure prediction: Methods and application -- 33. RNA structural bioinformatics -- Section VII. Therapeutic discovery -- 34. Structural bioinformatics in drugs discovery -- 35. B-Cell epitope prediction -- Section VIII. Future challenges -- 36. Methods to classify and predict the structure of membrane proteins -- 37. Protein motion: Simulation -- 38. The significance and impacts of protein disorder and conformational variants -- 39. Protein designability and engineering -- 40. Structural genomics of protein superfamilies -- Index
Materia Bioinformática
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Genética bioquímica
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Biología computacional
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Biología molecular
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Autor secundario Gu, Jenny, ed. lit.
Bourne, Philip E., ed. lit.
ISBN 9780470181058