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245 00 Immunomodulating drugs /|cedited by Vassil St. Georgiev 
       and Hideyo Yamaguchi 
260    New York :|bNew York Academy of Sciences,|c1993 
300    XVI, 816 p. :|bil. ;|c24 cm 
490 1  Annals of the New York Academy of Sciences,|xISSN 0077-
       8923 ;|v685 
500    "This volume is the result of a conference ... held by the
       New York Academy of Sciences on June 27-July 1, 1992 in 
       Washington, D.C."--P. v. 
504    Bibliografía por capítulos. -- Índices p. 813-816 
505 0  Preface ━ Part I. FK‐506: Chemistry and Biological 
       Evaluation: Immunomodulating Drugs: Major Advances in 
       Research and Development -- FK‐506: Its Role in 
       Immunosuppression -- Discovery of FK‐506 and Update -- 
       FK‐506–A Novel Immunosuppressant -- Structural Studies of
       Complexed FK‐506 Binding Protein -- Allograft and 
       Xenograft Acceptance under FK‐506 and Other 
       Immunosuppressant Treatment -- FK‐506 Inhibits the 
       IL‐2‐Independent Induction of the Activation Antigen CD 
       69 -- Comparison of FK‐506, Rapamycin, Ascomycin, and 
       Cyclosporine in Mouse Models of Host‐versus‐Graft 
       Disease and Heterotopic Heart Transplantation ━ Part II. 
       Immunosuppressive Properties of Rapamycin Rapamycin: In 
       Vitro Profile of a New Immunosuppressive Macrolide -- 
       Prevention and Treatment of Allograft Rejection in Vivo by
       Rapamycin: Molecular and Cellular Mechanisms of Action -- 
       Rapamycin Prolongs Survival of Murine Recipients of Fully 
       Allogeneic Donor Grafts When Administered during the 
       Graft‐versus‐Host Disease Process -- Effects of Orally 
       Administered Rapamycin in Animal Models of Arthritis and 
       Other Autoimmune Diseases -- Rapamycin's Inhibition of 
       Thymocyte Proliferation, Unlike That of Cyclosporin A or 
       Prednisolone, Is Not Associated with Cytotoxicity -- 
       Rapamycin's Inhibition Lymphocyte Proliferation in a 
       Poplked Lymph Node Model via an IL‐2‐Independent 
       Mechanism --   Rapamycin in a Porcine Renal Transplant 
       Model 
505 0  ━ Part III. 15‐Deoxyspergualin: Chemistry and 
       Immunosuppressive Action: Synthesis and Background 
       Chemistry of 15‐Deoxyspergualin -- 15‐Deoxyspergualin, a
       Novel Immunosuppressive Drug: Studies of the Mechanism of 
       Action -- Successful Treatment with a Novel 
       Immunosuppressive Agent, Deoxyspergualin, in Type II 
       Collagen‐Induced Arthritis in Mice -- Preclinical Studies
       with 15‐Deoxyspergualin in Various Animal Models for 
       Autoimmune Diseases -- 15‐Deoxyspergualin: A Novel 
       Immunosuppressive Drug with Clinical Potential -- 
       Deoxyspergualin in Allogeneic Kidney and Xenogeneic Islet 
       Transplantation: Early Clinical Trials -- Deoxyspergualin:
       Clinical Trials in Renal Graft Rejection -- A Member of 
       the Hsp70 Family of Heat‐Shock Proteins Is a Putative 
       Target for the Immunosuppressant 15‐Deoxyspergualin -- 
       Effects of 15‐Deoxyspergualin on the Expression of 
       Surface Immunoglobulin in 70Z/3.12 Murine Pre‐B Cell Line
       ━ Part IV. Guanine Arabinoside and Purine Nucleoside 
       Phosphorylase Inhibitors: Enzymes of the Purine Metabolism
       : Inhibition and Therapeutic Potential -- IMP 
       Dehydrogenase Inhibitors as Immunomodulators -- Guanine 
       Arabinoside as a Bone Marrow‐Purging Agent -- Application
       of X‐Ray Crystallographic Methods in the Design of Purine
       Nucleoside Phosphorylase Inhibitors -- Activities of Two 
       9‐Deazaguanine Analogue Inhibitors of Purine Nucleoside 
       Phosphorylase, CI‐972 and PD 141955, in Vitro and in Vivo
505 0  ━ Part V. Immunomodulating Activity of Experimental 
       Therapeutics: Levamisole‐Induced Neopterin Synthesis -- 
       Experimental Modulation of IL‐1 Production and Cell 
       Surface Molecule Expression by Levamisole -- Recent 
       Clinical Trials with Levamisole -- Sex Hormones as 
       Immunomodulators of Disease -- Corticosteroids as 
       Immunomodulators -- Androstenediol Regulates Systemic 
       Resistance against Lethal Infections in Mice -- Overview 
       on the Chemistry and Immunomodulating Properties of Novel 
       Pyrimidinones -- Bropirimine in Bladder Cancer: Clinical 
       Studies -- Immunosuppressive Activity of Mycophenolate 
       Mofetil -- Molecular Mechanisms of Immunosuppression by 
       Cyclosporins -- Study of the Immunosuppressive Properties 
       of Cyclosporine Analogues -- Suppression of Alloantigen 
       Presentation by Prodigiosin, a T Cell‐Specific 
       Immunosuppressant -- In Vivo and in Vitro Efficacy of 
       Fusidic Acid in HIV Infection -- In Vivo Antitumor 
       Activity of the Hypoxanthine Derivatives ST 789 and ST 689
       -- Syntheses of Macromolecular Immunomodulators and 
       Conjugates Employing Haloacetyl Reagents -- 
       Immunomodulating Activity of Myelopeptides: Clinical 
       Trials -- Structural Nature and Functions of Transfer 
       Factors -- Effect of Oral Administration of Heat‐Killed 
       Enterococcus faecalis FK‐23 on the 
       Leukocyte‐Reconstituting Capacity in Immunosuppressed 
       Dogs -- Antitumor and Antimicrobial Activities of 
       Enterococcal Preparation Orally Administered to Mice -- 
       Immunostimulating Peptide Derived from Soybean Protein -- 
       Two Simple Glucose Derivatives with Opposite 
       Immunoactivities -- Immunopharmacologic Study of 
       Glucofructan from Symphytum asperum Roots ━ CONFERENCE 
       LECTURESHIPS: The Edmrd Jenner Lecture: Biological 
       Spinoffs of Organ Transplantation -- The Pharmacology of 
       Azathioprine -- Immunopathogenesis of HIV Infection -- 
       Transcription Factors in Lymphoid Development      
505 0  ━ Part VI. Immunomodulating Activities of 
       Anti‐Infectious Drugs: Immunomodulating Drugs: Whence and
       Whither -- Immunomodulator Effects on the Friend Virus 
       Infection in Genetically Defined Mice -- Immunomodulating 
       Activity of Antifungal Drugs -- Immunopharmacologic 
       Properties of Inosine 5'‐Methyl Monophosphate (MIMP) -- 
       Immunomodulatory Properties of AZT -- Antiviral Activity 
       of a Synthetic Double‐Stranded Polyribonucleotide 
       Interferon Inducer in a Murine AIDS Retrovirus Model Role 
       of Augmentation of Natural Killer Cell Activity and 
       Synergy with Oral AZT ━ Part VII. Treatment of Infectious
       Diseases and Sepsis: Intervention by Immune Regulation: 
       Modulation of Cytokine Responses in Sepsis -- 
       Interventions for the Treatment of Septic Shock -- 
       Pleiotropic Effects of Transforming Growth Factor‐β on 
       Cells of the Immune System -- TGFβ and HIV Infectiona    
505 0  ━ Part VIII. Immunomodulating Properties of Peptides in 
       Allergic and Autoimmune Diseases: Cytokines and Modulation
       of Diseases of Immediate Hypersensitivity -- Therapeutic 
       Peptides That Block Interaction of T Cells with MHC in 
       Experimental Allergic Encephalomyelitis --Antigen 
       Presentation by the Murine Renal Proximal Tubule: A 
       Mechanism of Self Tolerance? ━ Part IX. Kamp Medicine 
       (Japanese Herbal Medicine) and Its Imrnunomodulating 
       Effects with Special Reference to Intractable Asthma: 
       Immunologic Aspects of Kampo Medicine -- Inhibition of 
       Hypersensitivity Reactions by Saiboku‐to (TJ‐96), 
       Particularly on Type IV Reaction -- Effect of Saiboku‐to 
       (TJ‐96) on Bronchial Asthma Induction of Glucocorticoid 
       Receptor, β–Adrenaline Receptor, IgE‐Fce Receptor 
       Expression and Its Effect on Experimental Immediate and 
       Late Asthmatic Reaction -- Effect of an Herbal Preparation,
       Saiboku‐to (TJ‐96), on Antigen‐Induced Airway 
       Hyperresponsiveness and Eosinophil Infiltration in 
       Actively Sensitized Guinea Pigs -- Effects of Saiboku‐to 
       (TJ‐96) on the Production of Platelet‐Activating Factor 
       in Human Neutrophils -- A Multicenter Clinical Trial of 
       TJ‐96 in Patients with Steroid‐Dependent Bronchial 
       Asthma A Comparison of Groups Allocated by the Envelope 
       Method ━ Part X. Cytokines and Regulation of the Immune 
       Response: Cytokines and Their Role as Growth Factors and 
       in Regulation of Immune Responses -- The Interleukin‐2 
       Receptor: A Target for Immunotherapy -- The Role of the T 
       Cell Receptor α Chain in Antigen‐Specific Immune 
       Suppression -- Increased Levels of Leukotriene B4 and 
       Interleukin‐8 in Psoriatic Skin -- NK Cells and 
       Interferon as Mediators of Biological Response 
       Modifier‐Mediated Protection against MCMV and HSV‐2 
       Infection in Normal and Immunocompromised Mice   
505 0  ━ Part XI. Drug Metabolizing Enzymes and the Immune 
       System: Immune Dysfunction Related to Drug‐Metabolizing 
       Enzymes -- Role of the Ah Receptor and the 
       Dioxin‐Inducible [Ah] Gene Battery in Toxicity, Cancer, 
       and Signal Transduction -- Autoantibodies against 
       Cytochromes P‐450 in Drug‐Induced Autoimmune Hepatitis -
       - Immunity to Halothane Metabolite‐Modified Proteins in 
       Halothane Hepatitis -- Effects of Small Doses of Dioxins 
       on the Immune System of Marmosets and Rats ━ Part XII. 
       Novel Strategies for Immunotherapy: Immunologic Approaches
       to the Therapy of HIV‐1 Infection -- Gene Transfer for 
       Therapy and Prophylaxis of HIV‐1 Infection -- Modulation 
       of Macrophage Function by Transforming Growth Factor β, 
       Interleukin‐4, and Interleukin‐10 -- Pseudomonas 
       Exotoxin and Recombinant Immunotoxins Derived from It -- 
       Superantigens in Infectious Diseases, Including AIDS -- 
       RNA Drug Therapy Acting via the 2–5A Synthetase/RNase L 
       Pathway -- Specific RNA Drug Therapy of Hepatitis Viruses 
       -- Immunorehabilitation in Patients with Herpes Simplex --
       Quantitative Determination of HLA‐DR Antigen Expression 
       on Cell Surfaces with Monoclonal Antibody by Dot‐ELISA --
       Role of Increase of Opiod Receptors in Granulocyte CDllb/
       CD18 Dysfunction -- Immunosuppressive Effects of 
       Lymphocyte‐Specific Histamine Congener Treatment of an 
       Adoptive Transfer Model ━ Part XIII. Vaccines: Recent 
       Progress in Development: Issues in the Development of a 
       Prophylactic HIV Vaccine -- T Cell Vaccines for Autoimmune
       Diseases -- Vaccines Based on Synthetic Polyions and 
       Peptides -- Advances in Influenza Virus Vaccine Research  
650 04 Inmunodepresores|vCongresos 
650 04 Inmunofarmacología|vCongresos 
650 04 Adyuvantes inmunológicos|xFarmacología|vCongresos 
650 04 Inmunodepresores|xFarmacología|vCongresos 
650 04 Inmunoterapia|vCongresos 
650 04 Medicina herbaria|vCongresos 
700 1  Georgiev, Vassil St.,|eed. lit. 
700 1  Yamaguchi, Hideyo,|eed. lit. 
710 2  New York Academy of Sciences,|eed. 
830  0 Annals of the New York Academy of Sciences ;|v685 
856 41 |uhttps://nyaspubs.onlinelibrary.wiley.com/toc/17496632/
       1993/685/1|zAcceso a texto completo 
927 0  310|bjc|d200221 
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